Our ingredients (A-Z)
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Alpha-lipoic acid (ALA) is a naturally occurring substance in the body that plays a crucial role as a versatile antioxidant in numerous biochemical processes. It not only neutralises harmful free radicals but also supports energy metabolism by promoting the conversion of glucose into energy. ALA helps regulate blood sugar levels, exhibits anti-inflammatory properties, and is increasingly recognised as a valuable supporter of liver and neurological health. These diverse functions make it an important component for overall wellbeing and bodily health. In addition to being synthesised by the body, ALA is also found in foods such as red meat, spinach, broccoli, potatoes, tomatoes, and peas.
Type of substance:
Sulphur-containing fatty acid
Origin:
Naturally synthesised by the body, but also found in foods such as meat and vegetables
Benefits:
- Neutralisation of free radicals:
ALA plays a crucial role in the body’s antioxidant defence by neutralising harmful free radicals and regenerating other antioxidants.
- Metabolic support:
Alpha-lipoic acid supports energy metabolism by helping convert macronutrients such as carbohydrates and fats into ATP, the primary source of cellular energy. ALA contributes to making energy metabolism more efficient while protecting cells from harmful free radicals.
- Inflammation regulation:
Its anti-inflammatory effects help reduce inflammation and thereby support the body in promoting comfort and wellbeing.
- Neuroprotection:
ALA has neuroprotective properties that may positively influence the health and function of the nervous system.
- Liver health:
Recent research suggests that ALA reduces oxidative stress and inflammation in the liver, thereby supporting liver health.
Scientific References:
Energy Metabolism:
Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling
The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview
α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects
Performance:
The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training
Exercise Performance Upregulatory Effect of R-α Lipoic Acid with γ Cyclodextrin
Alpha-Lipoic acid as a biological antioxidant
Cognitive Function:
Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus
Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis
α-lipoic acid in patients with autosomal dominant polycystic kidney disease
- Neutralisation of free radicals:
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Ashwagandha (Withania somnifera) is a plant widely used in Ayurvedic medicine, known for its adaptogenic properties. It helps the body cope better with stress and promotes overall well-being. Ashwagandha supports mental and physical vitality by promoting the balance of hormones that regulate stress levels. Furthermore, it is valued for its anti-inflammatory and antioxidant properties and may have positive effects on sleep quality and immune function. These diverse benefits make ashwagandha a valuable plant for supporting health.
Type of substance:
Adaptogenic plant/herb
Origin:
India, the Middle East and parts of Africa
Benefits:
- Stress management:
Ashwagandha helps to support the body in coping with stress and to regulate the balance of stress hormones.
- Energy and vitality:
It promotes physical and mental energy and can contribute to improving overall vitality.
- Anti-inflammatory effect:
Ashwagandha has anti-inflammatory properties and helps to reduce chronic inflammation in the body.
- Sleep quality:
Its calming properties can contribute to better sleep quality and more restful sleep.
- Immune function:
Ashwagandha supports the immune system by acting as an antioxidant and strengthening the body's defenses.
Scientific References:
Energy Metabolism:
Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials
A Prospective, Randomized Double-Blind, Placebo Controlled Study of Safety and Efficacy of a High Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized,
Placebo-controlled Clinical StudyEfficacy of Withania somnifera supplementation on adult's cognition and mood
Mental Health/Cognitive Function:
The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial
Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study
Effects of Acute Ashwagandha Ingestion on Cognitive Function
Performance:
Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis
Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial
A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults
Anxiety:
Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials
A Prospective, Randomized Double-Blind, Placebo Controlled Study of Safety and Efficacy of a High Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study
- Stress management:
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Beetroot (Beta vulgaris) is a nutrient-rich plant, particularly valued for its high content of natural nitrate compounds. These promote the formation of nitric oxide (NO), which plays a crucial role in endothelial function, cardiovascular health, and cognitive performance. By improving blood circulation, beetroot powder can optimize the oxygen supply to the brain and muscles, thus contributing to increased performance and vitality.
Type of substance:
Herbaceous plant/beet (Good source of nitrates)
Origin:
Derived from the root of the beetroot ( Beta vulgaris ), a plant originally from the Mediterranean region and now cultivated worldwide. Particularly high-quality varieties come from nutrient-rich soils in Europe and North America. After harvesting, the beetroot is gently dried and ground into a fine powder to preserve its valuable nutrients
Benefits:
- Endothelial function: The nitrate contained in beetroot is converted in the body to nitric oxide (NO), which relaxes blood vessels and improves blood flow. This contributes to the healthy function of the endothelium, the inner cell layer of blood vessels, which is essential for vascular health.
- Cardiovascular health: By lowering blood pressure, improving vascular elasticity, and reducing oxidative stress, beetroot powder actively supports heart health. It can also enhance athletic performance by optimizing oxygen utilization in the muscles.
- Inflammation regulation:
Its anti-inflammatory effects help reduce inflammation and thereby support the body in promoting comfort and wellbeing.
- Cognitive function: Improved blood flow, especially to the brain, can enhance cognitive performance, strengthen memory, and counteract age-related mental decline. Studies show that beetroot can contribute to maintaining brain health by supporting neurovascular function.
Scientific References:
Endothelial Function (blood circulation):
The Effects of Beetroot Juice on Blood Pressure, Microvascular Function and Large-Vessel Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Pilot Study in Healthy Older Adults
"Beet" the cold: beetroot juice supplementation improves peripheral blood flow, endothelial function, and anti-inflammatory status in individuals with Raynaud's phenomenon
A single dose of beetroot juice improves endothelial function but not tissue oxygenation in pregnant women: a randomized clinical trial
Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice
Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation
Cardiovascular Health:
Acute Supplementation with Nitrate-Rich Beetroot Juice Causes a Greater Increase in Plasma Nitrite and Reduction in Blood Pressure of Older Compared to Younger Adults
The Potential Benefits of Red Beetroot Supplementation in Health and Disease
Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial
Beetroot ( Beta Vulgaris L.) Extract Acutely Improves Heart Rate Variability Recovery Following Strength Exercise: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial-Pilot Study
Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation
Cognitive Function:
Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial
Effects of raw red beetroot consumption on metabolic markers and cognitive function in type 2 diabetes patients
Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation
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Boswellia serrata, also known as frankincense, is a plant primarily known for its anti-inflammatory and pain-relieving properties. In traditional medicine, boswellia is mainly used to support joint health and is of particular interest to people suffering from joint pain and inflammatory conditions such as arthritis. Boswellia helps reduce inflammation, thus supporting joint mobility. Furthermore, the plant has strong antioxidant properties that help reduce oxidative damage and promote health at the cellular level. These diverse benefits make boswellia an important natural aid in promoting joint health and overall well-being.
Type of substance:
Resin from the Boswellia plant
Origin:
It is primarily grown in India, North Africa and the Middle East.
Benefits:
- Joint health: Boswellia supports joint health by reducing inflammation, thus helping to maintain joint mobility and flexibility.
- Anti-inflammatory effect: The anti-inflammatory properties of Boswellia help to reduce inflammation in the body and relieve discomfort such as pain and swelling.
- Antioxidant effect: Boswellia protects cells from oxidative stress and promotes health at the cellular level by fighting harmful free radicals.
Scientific References:
Joint Health:
Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis
Efficacy of Curcumin and Boswellia for Knee Osteoarthritis: Systematic Review and Meta-Analysis
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial
A randomized, double blind, placebo controlled, cross over study to evaluate the analgesic activity of Boswellia serrata in healthy volunteers using mechanical pain model
Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
Anti-inflammatory:
Curcuma longa and Boswellia serrata Extracts Modulate Different and Complementary Pathways on Human Chondrocytes In Vitro: Deciphering of a Transcriptomic Study
An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases
Boswellic Acids and Their Role in Chronic Inflammatory Diseases
Antioxidant:
Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts
Boswellia Essential Oil: Natural Antioxidant as an Effective Antimicrobial and Anti-Inflammatory Agent
Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis
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B vitamins are a group of eight essential, water-soluble vitamins that play a key role in energy metabolism and are vital for overall health. They contribute to the conversion of macronutrients such as carbohydrates and fats into energy, support cognitive function, and can positively influence mood. B vitamins are particularly important for brain function, as they support the production of neurotransmitters, thus promoting mental clarity and concentration. Furthermore, they help reduce stress and stabilize mood, which enhances general well-being. These diverse benefits make B vitamins an indispensable component of a healthy, energetic life.
Type of substance:
Essential water-soluble vitamins
Origin:
They are mainly found in animal products, whole grain products, legumes and green vegetables.
Benefits:
- Energy metabolism: B vitamins support the conversion of carbohydrates, fats and proteins into energy, thus contributing to the maintenance of an efficient energy metabolism.
- Cognitive function: They promote brain health by supporting the formation of neurotransmitters, thus increasing mental performance and concentration.
- Mood and stress management: B vitamins play an important role in regulating stress hormones and can thus help reduce stress and stabilize mood.
The B vitamins and their functions:
- Vitamin B1 (Thiamine): Supports carbohydrate metabolism and is important for nerve function.
- Vitamin B2 (Riboflavin): Promotes energy metabolism and protects cells from oxidative stress.
- B3 (Niacin): Contributes to energy production from macronutrients and supports skin health.
- Vitamin B5 (Pantothenic acid): Is crucial for energy production and hormone synthesis.
- Vitamin B6 (pyridoxine): Plays a role in the formation of neurotransmitters and supports cognitive function.
- Vitamin B7 (Biotin): Promotes the metabolism of fats, carbohydrates and proteins.
- Vitamin B9 (folic acid): Important role in cell division and the formation of red blood cells.
- B12 (Cobalamin): Supports the formation of red blood cells and contributes to the maintenance of nerve function.
Scientific References:
Energy Metabolism:
A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial
The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial
B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review
Mood/Stress:
Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis
Efficacy of B vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Cognitive function:
Effects of Folic Acid and Vitamin B12, Alone and in Combination on Cognitive Function and Inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-blind Experimental Design
Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo Controlled Phase IIa Clinical Trial
Effects of Folic Acid Combined with DHA Supplementation on Cognitive Function and Amyloid-β-Related Biomarkers in Older
Adults with Mild Cognitive Impairment by a Randomized, Double Blind, Placebo-Controlled TrialEffect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double-blind, placebo-controlled trial
The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis
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Caffeine is a natural plant compound found in various foods such as coffee, tea, cocoa, and guarana. It is known for its cognitive-enhancing and performance-enhancing properties and is used worldwide as a refreshing and stimulating agent. Caffeine works by blocking adenosine receptors in the brain, leading to increased alertness and improved performance.
Type of substance:
Secondary plant compound (alkaloid)
Origin:
Caffeine occurs naturally in the seeds, leaves, and fruits of plants such as coffee plants (Coffea spp.), tea plants (Camellia sinensis), and guarana (Paullinia cupana). These plants are primarily native to tropical and subtropical regions.
Benefits:
- Cognitive function: Caffeine increases concentration, alertness and mental clarity, thereby supporting cognitive performance and memory.
- Performance: Caffeine improves physical performance by increasing endurance, delaying fatigue, and enhancing athletic performance.
Scientific References:
Cognitive Function:
Caffeine and Cognitive Functions in Sports: A Systematic Review and Meta-Analysis
Effect of Caffeine on Attention and Alertness Measured in a Home Setting, Using Web Based Cognition Tests
Repeated low-dose caffeine ingestion during a night of total sleep deprivation improves endurance performance and cognitive function in young recreational runners: A randomized, double-blind, placebo-controlled study
Performance:
Caffeine Timing Improves Lower-Body Muscular Performance: A Randomized Trial
Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta Analysis
Acute Effects of Caffeine Supplementation on Physical Performance, Physiological Responses, Perceived Exertion, and Technical-Tactical Skills in Combat Sports: A Systematic Review and Meta-Analysis
Effects of Caffeine Ingestion on Physical Performance in Elite Women Handball Players: A Randomized, Controlled Study
Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review
Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists
Repeated low-dose caffeine ingestion during a night of total sleep deprivation improves endurance performance and cognitive function in young recreational runners: A randomized, double-blind, placebo-controlled study
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Creatine is a naturally occurring substance primarily stored in muscles, serving as an energy source for short bursts of intense activity. It is particularly well-known for its performance-enhancing effects on physical performance and muscle function. Less well-known, but equally well-researched, are the positive effects of creatine on cognitive function, especially in stressful or mentally demanding situations. Creatine acts as an effective energy store and has profound effects on brain function and muscle strength.
Type of substance:
Amino acid derivative/energy carrier
Origin:
Creatine occurs naturally in animal products such as meat and fish. The body also produces it itself from the amino acids arginine, glycine, and methionine. Creatine is primarily stored in the muscles, but it is also present in the brain, heart, and other tissues. For supplements, it is usually produced synthetically because it offers high bioavailability and can supply the body with creatine directly.
Benefits:
- Cognitive Function: Studies have shown promise in creatine for improving mental performance. It supports ATP production, the brain's essential energy source, and can improve mental clarity and concentration, especially during mental fatigue or cognitive tasks under stress. Some studies indicate that creatine can enhance performance in tasks such as memory, reaction time, and problem-solving during periods of intense mental exertion.
- Performance: Creatine is widely known for its ability to enhance athletic performance, particularly during short, intense bursts of activity such as sprinting, lifting, and high-intensity interval training (HIIT). It increases ATP availability, allowing for faster energy delivery to muscles during exercise, thus improving performance and endurance.
- Muscle Function & Strength: Creatine improves muscle strength and mass by increasing muscle cell hydration and protein synthesis. It also has the benefit of supporting recovery after intense training sessions by reducing muscle breakdown and promoting protein synthesis. In the long term, regular creatine supplementation can lead to a significant increase in maximum muscle strength and size.
Scientific References:
Cognitive Function:
Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis
Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation
Use of creatine in the elderly and evidence for effects on cognitive function in young and old
Performance:
Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations
Creatine supplementation and endurance performance: surges and sprints to win the race
Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance
Muscle Function/Strength:
Creatine Supplementation and Skeletal Muscle Metabolism for Building Muscle Mass- Review of the Potential Mechanisms of Action
Creatine Prevents the Structural and Functional Damage to Mitochondria in Myogenic, Oxidatively Stressed C2C12 Cells and Restores Their Differentiation Capacity
Creatine Supplementation: An Update
Effects of Creatine Supplementation and Resistance Training on Muscle Strength Gains in Adults <50 Years of Age: A Systematic Review and Meta-Analysis
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Curcumin is a component of turmeric (Curcuma longa) and belongs to the group of polyphenols. It is known for its anti-inflammatory and antioxidant properties and has been used in traditional medicine for centuries. Curcumin interacts with various molecular signaling pathways in the body and is valued for its diverse potential health benefits.
Type of substance:
Secondary plant compound (polyphenol)
Origin:
Derived from the root of turmeric ( Curcuma longa ), which is native primarily to South and Southeast Asia, particularly countries like India, China, and Thailand. Due to the diverse uses of curcumin in traditional medicine and modern health research, the plant is now also cultivated in other tropical and subtropical regions.
Benefits:
- Anti-inflammatory effect: Curcumin can regulate inflammatory processes in the body and thus contribute to joint comfort and mobility.
- Supporting joint health: Due to its modulating effect on inflammatory messengers, curcumin can help with joint problems.
- Antioxidant effect: As a powerful antioxidant, curcumin protects cells from oxidative stress and contributes to overall health.
Scientific References:
Anti-inflammatory:
Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial
Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials
Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of Randomized Clinical Trials
Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis
Joint Health:
In patients with osteoarthritis, is curcumin, compared to placebo, effective in reducing pain?
Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study
Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four month, double-blind, randomized, placebo-controlled trial
Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial
Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial
A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms
Focus/Cognitive Function:
Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: a systematic review and dose-response meta-analysis of randomized controlled trials
Efficacy of Curcumin on Cognitive Function Scores in Women with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blind, Placebo-Controlled Clinical Trial
Curcumin intervention for cognitive function in different types of people: A systematic review and meta-analysis
Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population
Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia
Antioxidant:
Antioxidant Potential of Curcumin—A Meta-Analysis of Randomized Clinical Trials
The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta analysis of randomized controlled trials
Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials
The Effects of Curcumin Supplementation on Muscle Damage, Oxidative Stress, and Inflammatory Markers in Healthy Females with Moderate Physical Activity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Ginger extract is derived from the root of the ginger plant (Zingiber officinale) and is known for its anti-inflammatory and antioxidant properties. It has been used in traditional medicine for centuries and has proven to be a powerful aid in supporting the body during inflammatory processes. Ginger extract works by influencing pro-inflammatory enzymes and signaling pathways in the body.
Type of substance:
Especially secondary plant compounds (phenols, particularly gingerol).
Origin:
Obtained from the root of ginger ( Zingiber officinale ), which is primarily native to Southeast Asia. Today, ginger is also cultivated in other tropical and subtropical regions worldwide.
Benefits:
- Anti-inflammatory effect: Ginger extract can regulate inflammatory processes in the body and thus contribute to the relief of inflammation and related discomfort.
- Pain-relieving: Due to its anti-inflammatory effect, ginger extract is frequently used to support the treatment of joint pain and muscle tension.
Scientific References:
Anti-inflammatory:
Effect of Ginger on Inflammatory Diseases
Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials
Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials
The effect of ginger supplementation on IL2, TNFα, and IL1β cytokines gene expression levels in patients with active rheumatoid arthritis: A randomized controlled trial
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Ginseng is a secondary plant compound extracted from the roots of the ginseng plant (Panax spp.). It is known for its invigorating and cognitive-enhancing properties and has been valued in traditional medicine for centuries. Ginseng interacts with various biological processes and is appreciated for its diverse positive effects on both body and mind.
Type of substance:
Secondary plant metabolites (saponins, especially ginsenosides)
Origin:
Derived from the root of the ginseng plant (Panax ginseng, Panax quinquefolius), which is primarily native to East Asia (China, Korea) and North America. Due to high demand, ginseng is now also cultivated in other temperate regions.
Benefits:
- Anti-fatigue effect: Ginseng can help reduce physical and mental fatigue and improve overall resistance to stress.
- Cognitive function: Due to its adaptogenic properties, ginseng can support mental performance and contribute to concentration and mental clarity.
Scientific References:
Anti-Fatigue:
Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial
Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial
Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis
Ginseng and Ginseng Herbal Formulas for Symptomatic Management of Fatigue: A Systematic Review and Meta-Analysis
Cognitive Function:
Cognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double blind, placebo-controlled clinical trial
Effects of Korean Red Ginseng on Cognitive and Motor Function: A Double-blind, Randomized, Placebo-controlled Trial
Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomized, double-blind, placebo controlled, crossover study
Effect of Korean Red Ginseng in individuals exposed to high stress levels: a 6-week, double blind, randomized, placebo-controlled trial
Active ginseng components in cognitive impairment: Therapeutic potential and prospects for delivery and clinical study
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Glycine is a non-essential amino acid that plays a central role in various biological processes. It is known for its calming, cognitively supportive, and performance-enhancing properties and is both synthesized in the body and obtained through food. Glycine influences important neurotransmitter systems and contributes to optimal physical and mental function.
Type of substance:
Amino acid
Origin:
Glycine is produced by the body itself and is found in protein-rich foods such as meat, fish, eggs, and gelatin. It is a natural component of collagen, which is found in connective tissue.
Benefits:
- Sleep quality: Glycine can help improve sleep architecture, make it easier to fall asleep, and promote recovery during the night.
- Cognitive function: Through its role as a neurotransmitter, glycine can support brain function, promote mental clarity and positively influence memory processes.
- Performance: Glycine contributes to the synthesis of creatine, which is important for the energy supply of muscles and physical performance.
Scientific References:
Sleep Quality:
The Effects of Glycine on Subjective Daytime
Performance in Partially Sleep-Restricted Healthy VolunteersThe Sleep-Promoting and Hypothermic Effects of
Glycine are Mediated by NMDA Receptors in the Suprachiasmatic NucleusGlycine ingestion improves
subjective sleep quality in human volunteers, correlating with polysomnographic
changesThe effect of glycine administration
on the characteristics of physiological systems in human adults: A systematic
review
Cognitive Function:
Beneficial effects of glycine (bioglycine) on
memory and attention in young and middle-aged adultsGlycine and N‐acetylcysteine (GlyNAC)
supplementation in older adults improves glutathione deficiency, oxidative
stress, mitochondrial dysfunction, inflammation, insulin resistance,
endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results
of a pilot clinical trial
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L-theanine is a natural amino acid found primarily in green tea (Camellia sinensis). It is known for its calming yet concentration-enhancing effects. Through its interaction with neurotransmitters such as GABA, dopamine, and serotonin, L-theanine can improve cognitive function, increase attention, and regulate the body's stress response.
Type of substance:
Amino acid (non-proteinogenic amino acid)
Origin:
Obtained from the leaves of the tea plant (Camellia sinensis), which is primarily cultivated in China, Japan, and India. Particularly high concentrations of L-theanine are found in high-quality green tea, especially matcha. Due to its beneficial effects, L-theanine is also produced synthetically or extracted from tea leaves.
Benefits:
- Cognitive function: L-theanine supports synaptic plasticity and promotes alpha brain waves, which are associated with a relaxed yet alert mental state. This can improve memory, information processing, and learning.
- Attention: In combination with caffeine, L-theanine enhances mental clarity and promotes sustained concentration without the typical side effects such as nervousness or energy crashes. Studies show that it can extend attention span and increase reaction speed.
- Stress reduction: L-theanine has a calming effect without causing drowsiness. It reduces the release of stress hormones such as cortisol and promotes a balanced mental state. This helps build stress resilience and maintain emotional balance.
Scientific References:
Cognitive Function:
Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial
Effects of chronic l theanine administration in patients with major depressive disorder: an open-label study
Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study
The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review
Anti-Stress, Behavioral and Magnetoencephalographic Effects of an L Theanine-Based Nutrient Drink: A Randomized, Double-Blind, Placebo Controlled, Crossover Trial
Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study
Attention:
L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study
L-theanine and Caffeine Improve Sustained Attention, Impulsivity and Cognition in Children with Attention Deficit Hyperactivity Disorders by Decreasing Mind Wandering (OR29-04-19)
Effects of l-theanine on attention and reaction time response
L-theanine, a natural constituent in tea, and its effect on mental state
Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study
Acute effects of theanine, caffeine and theanine-caffeine combination on attention
Stress Resilience:
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L-tyrosine is a non-essential amino acid that plays an important role in the synthesis of neurotransmitters such as dopamine and norepinephrine. These neurotransmitters are crucial for cognitive function and physical performance . L-tyrosine is often used as a supplement to enhance mental clarity, concentration, and stamina, especially under stressful conditions or during intense physical activity.
Type of substance:
Amino acid
Origin:
L-Tyrosine is synthesized in the body from the amino acid phenylalanine, but is also found in protein-rich foods such as meat, fish, eggs, dairy products and legumes.
Benefits:
- Cognitive function: L-tyrosine can improve mental performance in stressful or tiring situations by promoting the production of important neurotransmitters.
- Performance: By supporting neurotransmitter production, L-tyrosine contributes to increased physical endurance and helps optimize performance during intense physical activities.
Scientific References:
Cognitive Function:
Tyrosine improves working memory in a multitasking environment.
Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands--A review.
Behavioral and cognitive effects of tyrosine intake in healthy human adults.
Performance:
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Quercetin is a plant polyphenol found in various fruits and vegetables such as apples, onions, and berries. It is known for its antioxidant and anti-inflammatory properties and is increasingly valued for its positive effects on cognitive function, physical performance, and energy metabolism. Quercetin influences various biochemical processes that improve both mental and physical performance and support the body's energy balance.
Type of substance:
Secondary plant compound (flavonoid)
Origin:
Quercetin is found in a variety of plant sources, particularly apples, onions, berries, grapes, and green tea. These plants are widespread globally, with quercetin being especially abundant in plant sources from warm climates.
Benefits:
- Cognitive function: Quercetin can support cognitive function by reducing oxidative damage in the brain and promoting mental clarity and concentration.
- Performance: Due to its anti-inflammatory and antioxidant properties, quercetin contributes to improved physical performance, especially during endurance exercise.
- Physical performance: Quercetin supports physical performance by delaying fatigue and promoting recovery after intense physical activity.
- Energy metabolism: It contributes to the optimization of energy metabolism by supporting mitochondrial function and increasing ATP production, leading to increased energy efficiency.
Scientific References:
Cognitive Function:
Effect of quercetin glycosides on cognitive functions and cerebral blood flow: a randomized, double-blind, and placebo-controlled study
The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial
Memory-Enhancing Effect of 8-Week Consumption of the Quercetin-Enriched Culinary Herbs-Derived Functional Ingredients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance.
The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms
Mitochondrial Function:
Quercetin stimulates trophoblast fusion via the mitochondrial function
Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells
Quercetin and the mitochondria: A mechanistic view
Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials
Athletic Performance:
Quercetin and endurance exercise capacity: a systematic review and meta-analysis
Quercetin supplementation promotes recovery after exercise-induced muscle injury: a systematic review and meta-analysis of randomized controlled trials
Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study
Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
Quercetin's influence on exercise performance and muscle mitochondrial biogenesis
Quercetin and its metabolite isorhamnetin promote glucose uptake through different signaling pathways in myotubes
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Quinine is a natural substance derived from the bark of the cinchona tree, known for its diverse health benefits. In addition to its historical use in treating malaria, quinine also possesses immunomodulating and anti-inflammatory properties. It supports the immune system by helping to regulate immune responses and can inhibit inflammatory processes in the body. These properties make quinine a valuable natural compound that promotes well-being and strengthens the body's defenses.
Type of substance:
Secondary plant compound (alkaloid)
Origin:
Obtained from the bark of the cinchona tree (Cinchona spp.), which is native to the tropical regions of South America, particularly the Andes Mountains of Peru, Ecuador, Colombia, and Bolivia. Due to the medicinal importance of quinine, the tree was later cultivated in other tropical areas, such as Indonesia and India.
Benefits:
- Immune system support: Quinine can contribute to modulating the immune system and thus support the body's own defenses.
- Anti-inflammatory effect: The compound can regulate inflammatory processes and helps to alleviate discomfort.
- Antioxidant properties: Quinine has an antioxidant effect and protects cells from harmful free radicals.
Scientific References:
Immune System
Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2
Potential of Quinine Sulfate for COVID-19 Treatment and Its Safety Profile: Review
Molecular Docking of Quinine Derivative as Inhibitor in Sars-Cov-2
Anti-inflammatory
Suppression of tumor cell proliferation by quinine via the inhibition of the tumor necrosis factor receptor-associated factor 6-AKT interaction
Protective effects of pyrroloquinoline quinine against oxidative stress induced cellular senescence and inflammation in human renal tubular epithelial cells via Keap1/Nrf2 signaling pathway
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
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Resveratrol is a polyphenol found in the skin of red grapes, berries, and certain plants. Known for its antioxidant and cell-protective properties, it plays a vital role in supporting energy metabolism, cognitive function, and mitochondrial health. By activating specific signaling pathways, resveratrol can help improve energy production, enhance brain function, and slow cellular aging.
Type of substance:
Secondary plant compound (polyphenol)
Origin:
Resveratrol is extracted from the skins of red wine grapes (Vitis vinifera), certain berries such as blueberries and cranberries, and the root of Japanese knotweed (Reynoutria japonica). Particularly high concentrations are found in grape skins and seeds, which are byproducts of wine production. Due to its health benefits, resveratrol is also produced synthetically or extracted from natural sources.
Benefits:
- Energy metabolism: Resveratrol activates enzymes such as sirtuins and AMPK, which optimize cellular metabolism and increase the efficiency of ATP production. This can contribute to increased physical energy and endurance.
- Cognitive function: Due to its neuroprotective properties, resveratrol can improve cerebral blood flow, reduce oxidative stress, and support anti-inflammatory mechanisms. Studies show that it can positively influence memory and cognitive performance.
- Mitochondrial function: Resveratrol supports mitochondrial function and biogenesis by providing antioxidant protection and increasing the efficiency of cellular energy production. This can be particularly beneficial for healthy aging and cell vitality.
Scientific References:
Energy Metabolism:
Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic Review
Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol promotes mitochondrial energy metabolism in exercise induced fatigued rats
Resveratrol shifts energy metabolism to increase lipid oxidation in healthy old mice
Mitochondrial Function:
Resveratrol improves mitochondrial function and protects against metabolic diseases by activating SIRT1 and PGC-1alpha
Resveratrol and Brain Mitochondria: a Review
Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia
Cognitive Function:
Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomized, double-blind, placebo-controlled, crossover study
Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials
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Rhodiola rosea, also known as rose root, is an adaptogenic plant traditionally used to promote physical and mental resilience. It is particularly known for its ability to reduce fatigue, support cognitive function, and increase stress resistance. Through its regulatory effects on the central nervous system and energy metabolism, Rhodiola helps maintain mental and physical performance even under stress.
Type of substance:
Adaptogenic plant/herb
Origin:
Extracted from the root of Rhodiola rosea, a resilient plant native to the cold, mountainous regions of Eurasia and North America. Particularly high concentrations of bioactive compounds are found in plants from Siberia, Scandinavia, and Mongolia. Due to its adaptogenic properties, Rhodiola rosea has been used in traditional medicine for centuries.
Benefits:
- Anti-fatigue: Rhodiola rosea supports energy production at the cellular level by promoting ATP synthesis in the mitochondria and reducing oxidative stress. This can reduce fatigue and increase physical and mental performance.
- Cognitive function: By modulating neurotransmitters such as dopamine and serotonin, Rhodiola improves concentration, memory, and mental alertness. Studies show that it reduces cognitive fatigue and maintains mental performance even under stress.
- Stress resilience: As an adaptogen, Rhodiola regulates the stress hormone system, particularly cortisol production, and helps the body adapt more quickly to stressful situations. This improves stress management and supports emotional balance.
Scientific References:
Stress Management / Resilience:
The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence.
A randomized, double-blind, placebo-controlled, parallel-group study of the standardized extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
A randomized trial of two
different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms.
Anti-Fatigue:
Acute Rhodiola rosea intake can improve endurance exercise performance.
The effects of an acute dose of Rhodiola rosea on endurance exercise performance.
The influence of adaptogens on ultraweak biophoton emission: a pilot experiment.
Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
A randomized, double-blind, placebo-controlled, parallel-group study of the standardized extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
Cognitive Function:
Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event related potential dual task study.
The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms.
Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
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Taurine is a sulfur-containing amino acid that plays a key role in many physiological processes, particularly in maintaining mitochondrial function, the aging process, and cognitive performance. This versatile substance is found in many tissues of the body, including the brain, heart, and muscles, and is often described as "semi-essential" because the body can synthesize taurine from other amino acids, but additional intake is required during certain life stages or periods of stress. Taurine has attracted considerable scientific interest due to its antioxidant properties, its support of cellular functions, and its impact on mitochondrial energy metabolism.
Type of substance:
Amino acid/antioxidant
Origin:
Taurine occurs naturally in animal products such as meat, fish, and milk, particularly in high concentrations in organs (e.g., liver, heart, and brain). The body can synthesize taurine itself, but not always in sufficient quantities, especially under certain conditions such as intense physical exercise or with age.
Benefits:
- Mitochondrial function: Taurine plays a vital role in energy metabolism, particularly in the mitochondria, the "powerhouses" of cells. It supports the stability of cell membranes and protects mitochondria from oxidative stress, a common cause of cellular dysfunction and age-related diseases. Studies have shown that taurine can increase mitochondrial ATP production, leading to improved energy supply for the body.
- Aging process: Taurine has antioxidant and anti-inflammatory properties that can have a positive influence on the aging process. It protects cells from free radicals generated by the natural aging process and environmental factors. Scientific studies suggest that taurine helps slow age-related cell degradation, maintain cell health, and extend lifespan.
- Cognitive Function: Taurine has neuroprotective properties and supports brain function by protecting the integrity of nerve cells and promoting neuronal communication. Studies show that taurine can improve cognitive performance by regulating neuronal excitability and supporting the production of neurotransmitters. Particularly in old age, taurine could help prevent or slow cognitive decline and neurodegenerative diseases such as Alzheimer's and Parkinson's.
Scientific References:
Mitochondrial Function:
The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant
Taurine prevents mitochondrial dysfunction and protects mitochondria from reactive oxygen species and deuterium toxicity
A role for taurine in mitochondrial function
The Important Role of Taurine in Oxidative Metabolism
Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials
Taurine supplementation associated with exercise increases mitochondrial activity and fatty acid oxidation gene expression in the subcutaneous white adipose tissue of obese women
Aging Process:
Taurine deficiency as a driver of aging
Taurine as a potential anti-aging therapy: the key to reversing the aging process? Short communication
Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview
Taurine linked with healthy aging
Taurine as a possible antiaging therapy: A controlled clinical trial on taurine antioxidant activity in women ages 55 to 70
Taurine levels modulate aging
Cognitive Function:
Roles of taurine in cognitive function of physiology, pathologies and toxicity
Taurine Supplementation as a Neuroprotective Strategy upon Brain Dysfunction in Metabolic Syndrome and Diabetes
The Effects of Dietary Taurine-Containing Jelly Supplementation on Cognitive Function and Memory Ability of the Elderly with Subjective Cognitive Decline
A taurine and caffeine-containing drink stimulates cognitive performance and well-being
Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A double-blind, placebo-controlled study
Evaluation of the neuroprotective effect of taurine in Alzheimer's disease using functional molecular imaging
Past Taurine Intake Has a Positive Effect on Present Cognitive Function in the Elderly
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Vitamin A is an essential fat-soluble vitamin that plays a central role in vision, the immune system, and cellular differentiation. Its effects on eye health, skin regeneration, and immune defense are particularly well-researched. Vitamin A exists in two main forms: as retinol (the active form from animal sources) and as provitamin A carotenoids (e.g., beta-carotene from plant sources), which can be converted to retinol in the body.
Type of substance:
Fat-soluble vitamin
Origin:
Vitamin A is derived from animal sources such as liver, egg yolks, and dairy products containing retinol. Plant sources provide provitamin A carotenoids, which are found in green, red, and orange vegetables such as carrots, sweet potatoes, and spinach. Synthetic forms of vitamin A are commonly used in dietary supplements.
Benefits:
- Immune system: Retinol plays a key role in regulating the immune response. It promotes the development and function of T cells and contributes to the integrity of the mucous membranes in the lungs and intestines, thereby reducing the risk of infection. Scientific studies show that vitamin A deficiency increases the risk of serious infections, especially respiratory diseases.
Scientific References:
Immune System:
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Vitamin C (ascorbic acid) is an essential, water-soluble vitamin that plays a key role in many physiological processes in the body. Its positive effects on the immune system, energy metabolism, and its antioxidant properties are particularly well-researched. As a powerful antioxidant, it protects cells from oxidative stress, supports enzymatic reactions in energy metabolism, and contributes to the function of both the innate and adaptive immune systems.
Type of substance:
Water-soluble vitamin/antioxidant
Origin:
Naturally abundant in citrus fruits, bell peppers, berries, kiwis, and leafy green vegetables. Vitamin C can also be produced synthetically, and in its bioavailable form as ascorbic acid or as buffered variants such as sodium ascorbate or calcium ascorbate in dietary supplements.
Benefits:
- Immune system: Vitamin C supports the production and function of immune cells such as phagocytes and T lymphocytes. It improves the activity of natural killer cells and promotes antibody production. Studies show that adequate intake can reduce the risk of infection and shorten the duration and severity of colds.
- Energy metabolism: As a cofactor for various enzymes, vitamin C plays an important role in ATP production in the mitochondria. It contributes to the synthesis of carnitine, a substance essential for the transport of fatty acids into the mitochondria. Studies suggest that a vitamin C deficiency can lead to increased fatigue and reduced physical performance.
- Antioxidant effect: Vitamin C is one of the most effective antioxidants in the human body. It neutralizes free radicals, protects cell membranes from oxidative damage, and regenerates other antioxidants such as vitamin E. Numerous studies show that it can help reduce oxidative stress, which is associated with chronic diseases such as cardiovascular disease and neurodegenerative processes.
Scientific References:
Immune System:
Effect of vitamin C on common cold: randomized controlled trial
Vitamin C reduces the severity of common colds: a meta-analysis
The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients
The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID 19: a randomized clinical trial
Performance:
Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence
Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial
Cognitive Function:
The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial
Protective effect of vitamin C on oxidative stress: a randomized controlled trial
Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo controlled trial
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Vitamin D is a fat-soluble vitamin that plays a central role in the immune system, bone health, and cognitive function. It is primarily synthesized in the body through exposure to sunlight and is essential for regulating calcium metabolism, modulating the immune system, and supporting neuronal function. Scientific studies show that optimal vitamin D levels are associated with improved immune function, increased bone density, and enhanced cognitive performance.
Type of substance:
Fat-soluble vitamin/hormone precursor
Origin:
Vitamin D is primarily synthesized by the body itself when the skin is exposed to UVB radiation. Dietary sources include fatty fish (salmon, mackerel, herring), liver, egg yolks, and fortified foods. Because many people in northern latitudes do not receive sufficient sunlight, vitamin D is often supplemented (e.g., vitamin D3, cholecalciferol).
Benefits:
- Immune system: Vitamin D regulates the function of immune cells such as T cells and macrophages and plays a key role in defending against infections. Studies show that adequate intake can reduce the risk of respiratory infections. Furthermore, vitamin D is involved in regulating inflammatory processes and may play a role in autoimmune diseases.
- Bone health: Vitamin D promotes the absorption of calcium and phosphorus in the intestines and is essential for bone mineralization. A deficiency has been shown to lead to osteoporosis and an increased risk of fractures. Clinical studies demonstrate that vitamin D supplementation can maintain bone density and reduce the risk of fractures in old age.
- Cognitive Function & Performance: Vitamin D receptors are located in various brain regions, including the hippocampus, which is crucial for memory. Research shows that low vitamin D levels are associated with cognitive decline, dementia, and reduced mental performance. Adequate intake can support mental clarity, memory, and overall cognitive performance.
Scientific References:
Immune System:
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials
A systematic review and meta-analysis of effect of vitamin D levels on the incidence of COVID-19
Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis
Sixteen-Week Vitamin D3 Supplementation Increases Peripheral T Cells in Overweight Black Individuals: Post hoc Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial
Vitamin D's Effect on Immune Function
Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial
Bone Health:
Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis
Vitamin D and bone health in adults: a systematic review and meta-analysis
Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta analysis of randomized controlled trials
Cognitive Function:
Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials
Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomized, double-blind, placebo-controlled trial
Vitamin D, cognition, and dementia: a systematic review and meta-analysis
The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta‐analysis of randomized controlled trials
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Vitamin E is an essential fat-soluble antioxidant that plays a crucial role in protecting cells from oxidative stress. It contributes to maintaining cell membranes, supports the immune system, and is important for cardiovascular and neurological health. Scientific studies show that vitamin E is particularly known for its antioxidant properties, which can prevent cell damage and reduce age-related cognitive decline and inflammatory processes.
Type of substance:
Fat-soluble vitamin/antioxidant
Origin:
Vitamin E is found in various vegetable oils (e.g., wheat germ oil, sunflower oil, olive oil), nuts, seeds, and green leafy vegetables. It exists in eight natural forms, with α-tocopherol being the most biologically active variant in the human body.
Benefits:
- Antioxidant Protection & Cell Health: Vitamin E is one of the most important antioxidants in the human body. It protects cell membranes from lipid peroxidation, a damaging process caused by free radicals. Studies show that vitamin E, especially in combination with other antioxidants such as vitamin C, helps reduce oxidative stress, which is associated with numerous chronic diseases.
- Cognitive Function & Neuroprotection: Scientific research suggests that vitamin E may have a positive impact on brain health. A meta-analysis of clinical trials shows that adequate vitamin E intake is associated with slower cognitive decline and a reduced risk of neurodegenerative diseases such as Alzheimer's. Vitamin E may protect nerve cells and reduce inflammation in the brain through its antioxidant properties.
- Cardiovascular health: Vitamin E helps prevent the oxidation of LDL cholesterol, a crucial factor in the development of atherosclerosis. While some studies suggest that vitamin E supplementation may reduce the risk of cardiovascular disease, the evidence remains inconsistent. Nevertheless, epidemiological data show that a diet rich in vitamin E correlates with better vascular function and a lower inflammatory status.
Scientific References:
Antioxidant & Anti-inflammatory Protection:
Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy
Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses
The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials
Cognitive Function:
The Role of Vitamin E in Slowing Down Mild Cognitive Impairment: A Narrative Review
Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis
A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer's disease
Cardiovascular Health:
Navigating the world of scientific research isn't always easy – especially when unreliable or distorted information circulates on social media. Often, a lack of expertise and an understanding of complex relationships are exploited to draw false conclusions.
To properly interpret research findings, it is important to understand the strengths and weaknesses of different study designs. The evidence pyramid provides a clear framework for this: it ranks studies according to their informative value and scientific quality.
At the top of the pyramid are systematic reviews and meta-analyses – they summarise the results of many high-quality studies and thus provide the strongest form of scientific evidence. These are followed by randomised controlled trials, then observational studies. The lower levels consist of animal and cell studies, which provide important foundations, but the results are not always directly transferable to humans.
Those who understand this hierarchy can better evaluate research results – and recognise more quickly which statements are actually supported by sound science.
At iüLabs, we place the utmost importance on the highest scientific standards. Wherever possible, we base the development of our products on research from the top end of the evidence pyramid – that is, on meta-analyses, systematic reviews, and randomised clinical trials.
Each ingredient is carefully selected by us based on its scientifically proven bioactive effects. We examine not only its individual effects but also its potential in combination with other ingredients.
This results in synergistic formulations that support multiple metabolic processes simultaneously and unlock the full potential of each individual ingredient.
We exclusively use ingredients that have solid scientific evidence – and whose properties precisely match the goals and requirements of our products.